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UPSC 2010: Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine ?
(a)Malaria is caused by several species of Plasmodium
(b)Man does not develop immunity to malaria during natural infection
(c)Vaccines can be developed only against bacteria
(d)Man is only an intermediate host and not the definitive host
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Not attemptedCorrect Answer: (b) Man does not develop immunity to malaria during natural infection
Unlike many viral or bacterial diseases, natural infection with Plasmodium does not generate long-lasting, sterilising immunity in humans; partial immunity develops only after repeated attacks and is species- and stage-specific. This weak naturally-acquired immunity makes it hard to design a vaccine that can elicit complete protection, which is why option (b) states the key hurdle. Options (a), (c) and (d) are either only partly relevant or incorrect. ([gktoday.in](https://www.gktoday.in/analysis-of-upsc-civil-services-2010-gs-paper-part-1/))
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What is the correct answer to this UPSC 2010 Science & Technology question?▼
The correct answer is option (b): Man does not develop immunity to malaria during natural infection. Watch the detailed video explanation in our Sherlocking Prelims course on UnlockIAS.
Which year was this Health & Diseases question asked in UPSC Prelims?▼
This question was asked in UPSC CSE Prelims 2010, GS Paper 1, as Question 21. It falls under Science & Technology > Health & Diseases.
What is the difficulty level of this UPSC question?▼
This question is rated "moderate". It requires sound conceptual understanding of the topic.
How many UPSC Prelims questions have been asked from Health & Diseases?▼
UPSC has asked 86 questions from Health & Diseases (under Science & Technology) across multiple years. Visit the topic page to see the full list and year-wise trends.