Which pathway in cellular respiration generates the most ATP?
- (a)Glycolysis
- (b)Krebs cycle
- (c)Electron transport chain
- (d)Fermentation
Answer
Why
Correct — C. Using NCERT's figures, with glycolysis NADH taken into the mitochondria:
Glycolysis: net 2 ATP, plus 2 NADH
Link reaction and Krebs cycle: 2 ATP, 8 NADH, 2 FADH₂
Electron transport: 10 NADH × 3 = 30, and 2 FADH₂ × 2 = 4
Chain total = 34 of the 38 ATP → option (c)
Why the others are wrong
- (a)Glycolysis — Glycolysis nets only 2 ATP per glucose, in the cytoplasm. Its bigger contribution is 2 NADH, whose energy is cashed in later by the electron transport chain.
- (b)Krebs cycle — The Krebs cycle makes just 2 ATP per glucose directly. Its real output is NADH and FADH₂, which yield ATP only when the electron transport chain oxidises them.
- (d)Fermentation — Fermentation nets only 2 ATP per glucose, all from glycolysis, and NCERT notes it releases less than seven per cent of the energy in glucose.
Concept
Aerobic respiration runs in three stages: glycolysis in the cytoplasm, the Krebs cycle in the mitochondrial matrix, and the electron transport system on the inner mitochondrial membrane.
The first two stages mostly strip electrons from glucose and load them onto NADH and FADH₂. In the third, those electrons pass along complexes I to IV to oxygen, the final hydrogen acceptor, and ATP synthase uses the energy released to make ATP.
That coupling is oxidative phosphorylation.
NCERT's 38 is a theoretical count that assumes 3 ATP per NADH and 2 per FADH₂. Modern biochemistry uses lower ratios, about 2.5 and 1.5, which puts the total nearer 30 to 32.
Either way, the electron transport chain makes most of it.
Key facts
- The electron transport system sits on the inner mitochondrial membrane, with oxygen as the final hydrogen acceptor.
- In NCERT's count, one NADH yields 3 ATP and one FADH₂ yields 2 ATP.
- NCERT puts the net gain from aerobic respiration of one glucose at 38 ATP.
- Fermentation nets only 2 ATP per glucose.
Study next
Common traps
- Crediting the Krebs cycle with the ATP, when it mainly produces NADH and FADH₂ for the chain.
- Counting fermentation as a separate ATP source, when its 2 ATP come from glycolysis.
Here the item compares the ATP yield of each stage, so the NADH-to-ATP conversion is the thing to know.
The mitochondrion also appears at 11 Sep 2024, 12:30, GA Q.23, where Mitochondria: Power house of the cell is a correctly matched pair, and at 9 Sep 2024, 16:00, GA Q.9, which asks for the illustration of its structure.
Related PYQs
No directly related past PYQ was found.